6xc3

X-ray diffraction
2.7Å resolution

Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CC12.1 and CR3022

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (6 distinct):
CR3022 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
CR3022 light chain Chain: L
Molecule details ›
Chain: L
Length: 221 amino acids
Theoretical weight: 24.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
CC12.1 light chain Chain: A
Molecule details ›
Chain: A
Length: 217 amino acids
Theoretical weight: 23.64 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
CC12.1 heavy chain Chain: B
Molecule details ›
Chain: B
Length: 220 amino acids
Theoretical weight: 23.15 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
Spike protein S1 Chain: C
Molecule details ›
Chain: C
Length: 231 amino acids
Theoretical weight: 26.1 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P0DTC2 (Residues: 319-541; Coverage: 18%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-1
Spacegroup: P41212
Unit cell:
a: 109.772Å b: 109.772Å c: 235.68Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.177 0.225
Expression systems:
  • Homo sapiens
  • Mus musculus
  • Trichoplusia ni