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Human Alpha-1,6-fucosyltransferase (FUT8) bound to GDP and A3-Asn

Source organism: Homo sapiens
Biochemical function: alpha-(1->6)-fucosyltransferase activity
Biological process: regulation of cellular response to oxidative stress
Cellular component: extracellular exosome

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EC 2.4.1.68: Glycoprotein 6-alpha-L-fucosyltransferase

Reaction catalysed:
GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine
Systematic name:
GDP-beta-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine) 6-alpha-L-fucosyltransferase
Alternative Name(s):
  • FucT
  • GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase
  • GDP-L-fucose-glycoprotein fucosyltransferase
  • GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine) 6-alpha-L-fucosyltransferase
  • GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine) 6-alpha-L-fucosyltransferase
  • GDP-fucose--glycoprotein fucosyltransferase
  • Glycoprotein fucosyltransferase
  • Guanosine diphosphofucose-glycoprotein fucosyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF14604
Domain description: Variant SH3 domain
Occurring in:
  1. Alpha-(1,6)-fucosyltransferase
The deposited structure of PDB entry 6x5t contains 8 copies of Pfam domain PF14604 (Variant SH3 domain) in Alpha-(1,6)-fucosyltransferase. Showing 1 copy in chain A.

PF19745
Domain description: Alpha-(1,6)-fucosyltransferase N- and catalytic domains
Occurring in:
  1. Alpha-(1,6)-fucosyltransferase
The deposited structure of PDB entry 6x5t contains 8 copies of Pfam domain PF19745 (Alpha-(1,6)-fucosyltransferase N- and catalytic domains) in Alpha-(1,6)-fucosyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001452
Domain description: SH3 domain
Occurring in:
  1. Alpha-(1,6)-fucosyltransferase
IPR036028
Domain description: SH3-like domain superfamily
Occurring in:
  1. Alpha-(1,6)-fucosyltransferase
IPR035653
Domain description: Alpha-(1,6)-fucosyltransferase, SH3 domain
Occurring in:
  1. Alpha-(1,6)-fucosyltransferase
IPR027350
Domain description: Glycosyltransferase family 23 (GT23) domain
Occurring in:
  1. Alpha-(1,6)-fucosyltransferase
IPR045573
Domain description: Alpha-(1,6)-fucosyltransferase, N- and catalytic domain
Occurring in:
  1. Alpha-(1,6)-fucosyltransferase
IPR015827
Domain description: Alpha-(1,6)-fucosyltransferase
Occurring in:
  1. Alpha-(1,6)-fucosyltransferase

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