› 6x4h

X-ray diffraction
2.9Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189211 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Sortilin Chain: A
Molecule details ›
Chain: A
Length: 663 amino acids
Theoretical weight: 74.26 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q99523 (Residues: 86-748; Coverage: 83%)
Gene name: SORT1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand UOY 1 x UOY
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: C2
Unit cell:
a: 161.458Å b: 79.444Å c: 111.545Å
α: 90° β: 127° γ: 90°
R-values:
R R work R free
0.204 0.201 0.253
Expression system: Cricetulus griseus

Quick links

Citations

1 citations in other articles

Regulation of lysosomal trafficking of progranulin by sortilin and prosaposin.
Du et al. (2022)