6x32

Electron Microscopy
3.8Å resolution

Wt pig RyR1 in complex with apoCaM, EGTA condition (class 1 and 2, closed)

Released:
Source organisms:
Related structures: EMD-22015

Function and Biology Details

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Peptidyl-prolyl cis-trans isomerase FKBP1B Chains: A, D, G, J
Molecule details ›
Chains: A, D, G, J
Length: 110 amino acids
Theoretical weight: 11.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68106 (Residues: 2-108; Coverage: 99%)
Gene names: FKBP12.6, FKBP1B, FKBP1L, FKBP9, OTK4
Ryanodine Receptor Chains: B, E, H, K
Molecule details ›
Chains: B, E, H, K
Length: 3800 amino acids
Theoretical weight: 422.85 KDa
Source organism: Sus scrofa
Calmodulin-1 Chains: C, F, I, L
Molecule details ›
Chains: C, F, I, L
Length: 146 amino acids
Theoretical weight: 16.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP23 (Residues: 3-148; Coverage: 98%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-22015
Expression system: Escherichia coli