Structure analysis

Structure of SARS-CoV-2 Nucleocapsid dimerization domain, P21 form

X-ray diffraction
1.45Å resolution
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 12000 Å2
Buried surface area: 5700 Å2
Dissociation area: 2,600 Å2
Dissociation energy (ΔGdiss): 36 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -61 kcal/mol
Symmetry number: 2
Assembly 2
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Multimeric state: homo dimer
Accessible surface area: 12200 Å2
Buried surface area: 5700 Å2
Dissociation area: 2,700 Å2
Dissociation energy (ΔGdiss): 35 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -52 kcal/mol
Symmetry number: 2

Macromolecules

Chains: A, B, C, D
Length: 137 amino acids
Theoretical weight: 15.59 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DTC9 (Residues: 247-364; Coverage: 28%)
Gene name: N

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