› 6wyg

X-ray diffraction
2.27Å resolution

Crystal structure of Human H-chain Ferritin variant 157C Delta C-star Modified with a RAFT agent

Released:
DOI: 10.2210/pdb6wyg/pdb
PDB 6wyg coloured by chain and viewed from the front.
PDB 6wyg coloured by chain and viewed from the side.
PDB 6wyg coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Anisotropic Dynamics and Mechanics of Macromolecular Crystals Containing Lattice-Patterned Polymer Networks.
Han K, Bailey JB, Zhang L, Tezcan FA
J Am Chem Soc 142 19402-19410 (2020)
PMID: 33124805

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin heavy chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 182 amino acids
Theoretical weight: 21.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02794 (Residues: 2-183; Coverage: 100%)
Gene names: FTH, FTH1, FTHL6, OK/SW-cl.84, PIG15
Sequence domains: Ferritin-like domain

Ligands and Environments

3 bound ligands:
Ligand FE 9 x FE
Ligand CA 8 x CA
Ligand RFT 4 x RFT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: R32
Unit cell:
a: 126.81Å b: 126.81Å c: 281.285Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.198 0.26
Expression system: Escherichia coli

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