Structure analysis

High curvature lateral interaction within a 13-protofilament, Taxol stabilized microtubule

Electron Microscopy
3.3Å resolution
Source organism: Bos taurus
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 58700 Å2
Buried surface area: 15600 Å2
Dissociation area: 800 Å2
Dissociation energy (ΔGdiss): -9 kcal/mol
Dissociation entropy (TΔSdiss): 16 kcal/mol
Interface energy (ΔGint): -99 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, C
Length: 451 amino acids
Theoretical weight: 50.2 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P81947 (Residues: 1-451; Coverage: 100%)
Pfam:

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Chains: B, D
Length: 445 amino acids
Theoretical weight: 49.95 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q6B856 (Residues: 1-445; Coverage: 100%)
Gene name: TUBB2B
Pfam:

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