X-ray diffraction
2.87Å resolution

Takifugu rubripes VKOR-like with warfarin


Function and Biology Details

Reaction catalysed:
Phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Vitamin-K-epoxide reductase (warfarin-sensitive) Chain: A
Molecule details ›
Chain: A
Length: 414 amino acids
Theoretical weight: 46.78 KDa
Source organisms: Expression system: Komagataella pastoris
  • Canonical: K0NYR4 (Residues: 1-145, 146-238; Coverage: 100%)
  • Canonical: Q6TEK8 (Residues: 7-175; Coverage: 97%)
Gene name: Vkorc1l1
Sequence domains:

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: I222
Unit cell:
a: 65.503Å b: 93.386Å c: 162.973Å
α: 90° β: 90° γ: 90°
R R work R free
0.243 0.241 0.286
Expression system: Komagataella pastoris