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Structure of radical S-adenosylmethionine methyltransferase, TsrM, from Kitasatospora setae with tryptophan substrate and SAM analog (aza-SAM) bound

X-ray diffraction
2.19Å resolution
PDB entry 6wtf coloured by chain, front view.
PDB entry 6wtf coloured by chain, side view.
PDB entry 6wtf coloured by chain, top view.
Source organism: Kitasatospora setae KM-6054
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: B12-binding domain-containing protein
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Multimeric state: monomeric
Accessible surface area: 19715.87 Å2
Buried surface area: 2809.82 Å2
Dissociation area: 1,218.52 Å2
Dissociation energy (ΔGdiss): 17.53 kcal/mol
Dissociation entropy (TΔSdiss): 7.88 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-122936
Assembly 2
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Assembly Name: B12-binding domain-containing protein
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Multimeric state: monomeric
Accessible surface area: 19461.02 Å2
Buried surface area: 2806.49 Å2
Dissociation area: 1,221.77 Å2
Dissociation energy (ΔGdiss): 18 kcal/mol
Dissociation entropy (TΔSdiss): 7.88 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-122936

Macromolecules

Tryptophan-C2-methyltransferase containing B12-binding domain
Chains: A, B
Length: 575 amino acids
Theoretical weight: 64.14 KDa
Source organism: Kitasatospora setae KM-6054
Expression system: Escherichia coli
UniProt:
  • Canonical: E4N8S5 (Residues: 1-575; Coverage: 100%)
Gene name: KSE_17820
Pfam:
InterPro:
Tryptophan-C2-methyltransferase containing B12-binding domain in PDB entry 6wtf, assembly 1, front view.
Tryptophan-C2-methyltransferase containing B12-binding domain in PDB entry 6wtf, assembly 1, side view.
Tryptophan-C2-methyltransferase containing B12-binding domain in PDB entry 6wtf, assembly 1, top view.
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