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Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with inositol hexakisphosphate and Mg, presoaked with 5-IP7, Mg and Fluoride, soaking 20min in the absence of Fluoride.

Source organism: Homo sapiens
Biochemical function: hydrolase activity
Biological process: not assigned
Cellular component: not assigned

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EC 3.6.1.61: Diadenosine hexaphosphate hydrolase (ATP-forming)

Reaction catalysed:
P(1),P(4)-bis(5'-adenosyl)tetraphosphate + H(2)O = ATP + AMP
Systematic name:
P(1),P(6)-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming)
Alternative Name(s):
  • Ndx1

EC 3.6.1.62: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase

Reaction catalysed:
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] + H(2)O = N(7)-methylguanosine 5'-diphosphate + 5'-phospho-[mRNA]
Systematic name:
5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] N(7)-methylguanosine-5'-diphosphate phosphohydrolase
Alternative Name(s):
  • D10 decapping enzyme
  • D10 protein
  • D9 protein
  • Dcp2
  • Decapping enzyme
  • M(7)GpppN-mRNA hydrolase
  • M(7)GpppN-mRNA m(7)GDP phosphohydrolase
  • NUDT16

EC 3.6.1.59: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase

Reaction catalysed:
A 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H(2)O = N(7)-methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA]
Systematic name:
5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] N(7)-methylguanosine 5'-phosphate phosphohydrolase
Alternative Name(s):
  • DcpS
  • M(7)GpppN m(7)GMP phosphohydrolase
  • M(7)GpppX diphosphatase
  • M(7)GpppX pyrophosphatase

EC 3.6.1.52: Diphosphoinositol-polyphosphate diphosphatase

Reaction catalysed:
Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
Systematic name:
Diphospho-myo-inositol-polyphosphate diphosphohydrolase
Alternative Name(s):
  • DIPP
  • Diphosphoinositol-polyphosphate phosphohydrolase

EC 3.6.1.10: Endopolyphosphatase

Reaction catalysed:
Polyphosphate + n H(2)O = (n+1) oligophosphate
Systematic name:
Polyphosphate polyphosphohydrolase
Alternative Name(s):
  • Metaphosphatase
  • Polymetaphosphatase
  • Polyphosphatase
  • Polyphosphate depolymerase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00293
Domain description: NUDIX domain
Occurring in:
  1. Diphosphoinositol polyphosphate phosphohydrolase 1
The deposited structure of PDB entry 6wof contains 1 copy of Pfam domain PF00293 (NUDIX domain) in Diphosphoinositol polyphosphate phosphohydrolase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000086
Domain description: NUDIX hydrolase domain
Occurring in:
  1. Diphosphoinositol polyphosphate phosphohydrolase 1
IPR020084
Domain description: NUDIX hydrolase, conserved site
Occurring in:
  1. Diphosphoinositol polyphosphate phosphohydrolase 1
IPR047198
Domain description: Diphosphoinositol polyphosphate phosphohydrolase-like, NUDIX domain
Occurring in:
  1. Diphosphoinositol polyphosphate phosphohydrolase 1
IPR015797
Domain description: NUDIX hydrolase-like domain superfamily
Occurring in:
  1. Diphosphoinositol polyphosphate phosphohydrolase 1

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