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X-ray diffraction
1.6Å resolution

Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with inositol hexakisphosphate and Mg, presoaked with 5-IP7, Mg and Fluoride, soaking 20min in the absence of Fluoride.

Released:

Function and Biology Details

Reaction catalysed:
Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Diphosphoinositol polyphosphate phosphohydrolase 1 Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 19.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95989 (Residues: 1-148; Coverage: 86%)
Gene names: DIPP, DIPP1, NUDT3
Sequence domains: NUDIX domain

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 46.062Å b: 59.827Å c: 62.729Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.124 0.123 0.148
Expression system: Escherichia coli