› 6wna

X-ray diffraction
2.4Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-134885 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
IgG receptor FcRn large subunit p51 Chain: A
Molecule details ›
Chain: A
Length: 264 amino acids
Theoretical weight: 29.43 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P55899 (Residues: 27-290; Coverage: 77%)
Gene names: FCGRT, FCRN
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Immunoglobulin heavy constant gamma 4 Chain: H
Molecule details ›
Chain: H
Length: 207 amino acids
Theoretical weight: 23.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01861 (Residues: 118-324; Coverage: 52%)
Gene name: IGHG4
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, FUC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: C2221
Unit cell:
a: 68.095Å b: 122.096Å c: 179.446Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.214 0.263
Expression system: Homo sapiens

Quick links

Citations

1 citations in other articles

Tag-free, specific conjugation of glycosylated IgG1 antibodies using microbial transglutaminase.
Hadjabdelhafid-Parisien et al. (2022)