Structure analysis

PAK4 kinase domain in complex with beta-catenin Ser675 substrate peptide

X-ray diffraction
2.2Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 13800 Å2
Buried surface area: 850 Å2
Dissociation area: 450 Å2
Dissociation energy (ΔGdiss): 2 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -2 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 346 amino acids
Theoretical weight: 39.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O96013 (Residues: 286-591; Coverage: 52%)
  • Best match: O96013-2 (Residues: 109-426)
Gene names: KIAA1142, PAK4
Pfam: Protein kinase domain

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Chain: B
Length: 7 amino acids
Theoretical weight: 862 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P35222 (Residues: 671-677; Coverage: 1%)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286

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