X-ray diffraction
3.08Å resolution

Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody CR3022


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
CR3022 Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
CR3022 Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 221 amino acids
Theoretical weight: 24.38 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Spike protein S1 Chain: C
Molecule details ›
Chain: C
Length: 231 amino acids
Theoretical weight: 26.1 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Trichoplusia ni
  • Canonical: P0DTC2 (Residues: 319-541; Coverage: 18%)
Gene names: 2, S
Sequence domains: Betacoronavirus spike glycoprotein S1, receptor binding

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P4122
Unit cell:
a: 147.535Å b: 147.535Å c: 200.156Å
α: 90° β: 90° γ: 90°
R R work R free
0.224 0.223 0.243
Expression systems:
  • Homo sapiens
  • Trichoplusia ni