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Structure of unphosphorylated human IRE1 bound to G-9807

X-ray diffraction
2.08Å resolution
PDB entry 6w3k coloured by chain, front view.
PDB entry 6w3k coloured by chain, side view.
PDB entry 6w3k coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase/endoribonuclease IRE1
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Multimeric state: homo dimer
Accessible surface area: 37083.34 Å2
Buried surface area: 2628.25 Å2
Dissociation area: 1,314.12 Å2
Dissociation energy (ΔGdiss): -11.98 kcal/mol
Dissociation entropy (TΔSdiss): 14.57 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-130962

Macromolecules

Serine/threonine-protein kinase/endoribonuclease IRE1
Chain: A
Length: 434 amino acids
Theoretical weight: 49.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75460 (Residues: 547-977; Coverage: 45%)
Gene names: ERN1, IRE1
Pfam:
InterPro:
Serine/threonine-protein kinase/endoribonuclease IRE1 in PDB entry 6w3k, assembly 1, front view.
Serine/threonine-protein kinase/endoribonuclease IRE1 in PDB entry 6w3k, assembly 1, side view.
Serine/threonine-protein kinase/endoribonuclease IRE1 in PDB entry 6w3k, assembly 1, top view.
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