6w2n

X-ray diffraction
1.88Å resolution

Trypanosoma cruzi Malic Enzyme in complex with inhibitor (MEC009)

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Malic enzyme Chain: A
Molecule details ›
Chain: A
Length: 554 amino acids
Theoretical weight: 61.61 KDa
Source organism: Trypanosoma cruzi strain CL Brener
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q4DJ68 (Residues: 12-565; Coverage: 98%)
Gene name: Tc00.1047053505183.30
Sequence domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: P43212
Unit cell:
a: 73.835Å b: 73.835Å c: 234.506Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.193 0.222
Expression system: Escherichia coli BL21(DE3)