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Cryo-EM structure of 5HT3A receptor in presence of Ondansetron

Electron Microscopy
3.06Å resolution
PDB entry 6w1m coloured by chain, front view.
PDB entry 6w1m coloured by chain, side view.
PDB entry 6w1m coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
homo pentamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 5-hydroxytryptamine-3A receptor complex
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Multimeric state: homo pentamer
Accessible surface area: 99073.96 Å2
Buried surface area: 37214.85 Å2
Dissociation area: 15,022.89 Å2
Dissociation energy (ΔGdiss): 194.57 kcal/mol
Dissociation entropy (TΔSdiss): 64.77 kcal/mol
Symmetry number: 5
PDBe Complex ID: PDB-CPX-150140
Complex Portal ID: CPX-274

Macromolecules

5-hydroxytryptamine receptor 3A
Chains: A, B, C, D, E
Length: 450 amino acids
Theoretical weight: 52.04 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23979 (Residues: 34-489; Coverage: 97%)
Gene names: 5ht3, Htr3, Htr3a
Pfam:
InterPro:
5-hydroxytryptamine receptor 3A in PDB entry 6w1m, assembly 1, front view.
5-hydroxytryptamine receptor 3A in PDB entry 6w1m, assembly 1, side view.
5-hydroxytryptamine receptor 3A in PDB entry 6w1m, assembly 1, top view.
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