Structure analysis

Engineered TTLL6 mutant bound to gamma-elongation analog

X-ray diffraction
2.66Å resolution
Source organism: Mus musculus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: monomeric
Accessible surface area: 17900 Å2
Buried surface area: 1600 Å2
Dissociation area: 50 Å2
Dissociation energy (ΔGdiss): -1 kcal/mol
Dissociation entropy (TΔSdiss): 1 kcal/mol
Interface energy (ΔGint): -29 kcal/mol
Symmetry number: 1
Assembly 3 (preferred)
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Multimeric state: monomeric
Accessible surface area: 17800 Å2
Buried surface area: 5200 Å2
Dissociation area: 150 Å2
Dissociation energy (ΔGdiss): -1 kcal/mol
Dissociation entropy (TΔSdiss): 1 kcal/mol
Interface energy (ΔGint): -31 kcal/mol
Symmetry number: 1
Assembly 4
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, B, C, D
Length: 453 amino acids
Theoretical weight: 53.35 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: A4Q9E8 (Residues: 51-503; Coverage: 55%)
Gene name: Ttll6
Pfam: Tubulin-tyrosine ligase family

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