› 6vzl

X-ray diffraction
2.07Å resolution

Crystal structure of human PPARgamma ligand binding domain in complex with GW1929

Released:
DOI: 10.2210/pdb6vzl/pdb
PDB 6vzl coloured by chain and viewed from the front.
PDB 6vzl coloured by chain and viewed from the side.
PDB 6vzl coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structural mechanism underlying ligand binding and activation of PPARγ.
Shang J, Kojetin DJ
Structure 29 940-950.e4 (2021)
PMID: 33713599

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 275 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 231-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand EDK 2 x EDK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 92.849Å b: 62.131Å c: 119.116Å
α: 90° β: 102.17° γ: 90°
R-values:
R R work R free
0.253 0.251 0.289
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 citations in other articles

Two steps, one ligand: How PPARγ binds small-molecule agonists.
Siclari et al. (2021)