6vzl

X-ray diffraction
2.07Å resolution

Crystal structure of human PPARgamma ligand binding domain in complex with GW1929

Released:
Source organism: Homo sapiens
Primary publication:
Structural mechanism underlying ligand binding and activation of PPARγ.
Structure 29 940-950.e4 (2021)
PMID: 33713599

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 275 amino acids
Theoretical weight: 31.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 231-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 92.849Å b: 62.131Å c: 119.116Å
α: 90° β: 102.17° γ: 90°
R-values:
R R work R free
0.253 0.251 0.289
Expression system: Escherichia coli BL21(DE3)