6vwf

X-ray diffraction
2.64Å resolution

Structure of ALDH9A1 complexed with NAD+ in space group C222

Released:

Function and Biology Details

Reactions catalysed:
4-aminobutanal + NAD(+) + H(2)O = 4-aminobutanoate + NADH
4-trimethylammoniobutanal + NAD(+) + H(2)O = 4-trimethylammoniobutanoate + NADH
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
4-trimethylaminobutyraldehyde dehydrogenase Chains: A, B
Molecule details ›
Chains: A, B
Length: 494 amino acids
Theoretical weight: 53.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49189 (Residues: 1-494; Coverage: 100%)
Gene names: ALDH4, ALDH7, ALDH9, ALDH9A1
Sequence domains: Aldehyde dehydrogenase family

Ligands and Environments


Cofactor: Ligand NAD 2 x NAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: C222
Unit cell:
a: 158.148Å b: 163.466Å c: 84.341Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.218 0.273
Expression system: Escherichia coli