6vr6

X-ray diffraction
2.5Å resolution

Structure of ALDH9A1 complexed with NAD+ in space group P1

Released:

Function and Biology Details

Reactions catalysed:
4-aminobutanal + NAD(+) + H(2)O = 4-aminobutanoate + NADH
4-trimethylammoniobutanal + NAD(+) + H(2)O = 4-trimethylammoniobutanoate + NADH
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
4-trimethylaminobutyraldehyde dehydrogenase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 493 amino acids
Theoretical weight: 53.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49189 (Residues: 2-494; Coverage: 100%)
Gene names: ALDH4, ALDH7, ALDH9, ALDH9A1
Sequence domains: Aldehyde dehydrogenase family

Ligands and Environments


Cofactor: Ligand NAD 8 x NAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P1
Unit cell:
a: 82.785Å b: 90.297Å c: 145.236Å
α: 89.37° β: 84.04° γ: 73.87°
R-values:
R R work R free
0.214 0.213 0.269
Expression system: Escherichia coli