Function and Biology Details
Reactions catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Endonucleolytic cleavage to 5'-phosphomonoester.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Integrase, C-terminal, retroviral
- Integrase, catalytic core
- Protein phosphatase 2A, regulatory B subunit, B56
- Integrase, C-terminal domain superfamily, retroviral
- Ribonuclease H-like superfamily
- Ribonuclease H superfamily
- Integrase, N-terminal zinc-binding domain
- DNA-binding protein 7a-e
4 more domains
Structure analysis Details
Assembly composition:
hetero dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-120781 (preferred)
Entry contents:
2 distinct polypeptide molecules
3 distinct DNA molecules
3 distinct DNA molecules
Macromolecules (5 distinct):
DNA-binding protein 7d; Integrase
Molecule details ›
Chains: A, B, C, D
Length: 390 amino acids
Theoretical weight: 43.65 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 390 amino acids
Theoretical weight: 43.65 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
- Canonical:
P39476 (Residues: 1-64; Coverage: 100%) - Canonical: P14078 (Residues: 1168-1462; Coverage: 20%)
Sequence domains:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Molecule details ›
Chains: E, F
Length: 343 amino acids
Theoretical weight: 40.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Protein phosphatase 2A regulatory B subunit (B56 family)
Length: 343 amino acids
Theoretical weight: 40.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q13362 (Residues: 30-372; Coverage: 66%)
Sequence domains: Protein phosphatase 2A regulatory B subunit (B56 family)
