› 6vgi

X-ray diffraction
2.61Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148927 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arachidonate 5-lipoxygenase-activating protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 171 amino acids
Theoretical weight: 19.33 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P20292 (Residues: 2-161; Coverage: 99%)
Gene names: ALOX5AP, FLAP
Sequence domains: MAPEG family

Ligands and Environments

2 bound ligands:
Ligand QY7 6 x QY7
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: C2
Unit cell:
a: 214.418Å b: 66.297Å c: 109.43Å
α: 90° β: 101.53° γ: 90°
R-values:
R R work R free
0.259 0.258 0.276
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators.
Gilbert et al. (2021)
3 other articles

2 mentions without citation

Substituted 1,2,4-Triazoles as Novel and Selective Inhibitors of Leukotriene Biosynthesis Targeting 5-Lipoxygenase-Activating Protein.
Olğaç et al. (2023)
1 more