6vah

X-ray diffraction
2.11Å resolution

Crystal structure of human TEAD2 transcription factor in complex with Flufenamic acid derivative

Released:
Source organism: Homo sapiens
Entry authors: Halabelian L, Zeng H, Dong A, Li Y, Melin L, Gagnon A, Bountra C, Edwards AM, Arrowsmith CH, Santhakumar V, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional enhancer factor TEF-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 240 amino acids
Theoretical weight: 27.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15562 (Residues: 217-447; Coverage: 52%)
Gene names: TEAD2, TEF4
Sequence domains: YAP binding domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 120.792Å b: 61.307Å c: 79.862Å
α: 90° β: 118.1° γ: 90°
R-values:
R R work R free
0.206 0.204 0.242
Expression system: Escherichia coli BL21(DE3)