› 6v87

X-ray diffraction
2.4Å resolution

Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with 4-Hydroxytamoxifen

Released:
DOI: 10.2210/pdb6v87/pdb
PDB 6v87 coloured by chain and viewed from the front.
PDB 6v87 coloured by chain and viewed from the side.
PDB 6v87 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Fanning SW, Greene GL

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Estrogen receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 262 amino acids
Theoretical weight: 30.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P03372 (Residues: 307-554; Coverage: 42%)
Gene names: ESR, ESR1, NR3A1
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:
Ligand OHT 2 x OHT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: C2
Unit cell:
a: 104.201Å b: 55.067Å c: 97.479Å
α: 90° β: 113.477° γ: 90°
R-values:
R R work R free
0.245 0.242 0.271
Expression system: Escherichia coli

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