6v76

X-ray diffraction
2.75Å resolution

Crystal Structure of Human PKM2 in Complex with L-valine

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + pyruvate = ADP + phosphoenolpyruvate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pyruvate kinase PKM Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 550 amino acids
Theoretical weight: 60.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14618 (Residues: 1-531; Coverage: 100%)
Gene names: OIP3, PK2, PK3, PKM, PKM2
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21
Unit cell:
a: 81.04Å b: 154.98Å c: 91.96Å
α: 90° β: 102.36° γ: 90°
R-values:
R R work R free
0.225 0.223 0.265
Expression system: Escherichia coli