› 6v69

Electron Microscopy
4.2Å resolution

Structures of GCP4 and GCP5 in the native human gamma-tubulin ring complex

Released:
DOI: 10.2210/pdb6v69/pdb
PDB entry 6v69 coloured by chain, front view.
PDB entry 6v69 coloured by chain, side view.
PDB entry 6v69 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Asymmetric Molecular Architecture of the Human γ-Tubulin Ring Complex.
Wieczorek M, Urnavicius L, Ti SC, Molloy KR, Chait BT, Kapoor TM
Cell 180 165-175.e16 (2020)
PMID: 31862189
Related structures: EMD-21060

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188741 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Gamma-tubulin complex component 5 Chain: J
Molecule details ›
Chain: J
Length: 1024 amino acids
Theoretical weight: 118.47 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96RT8 (Residues: 1-1024; Coverage: 100%)
Gene names: GCP5, KIAA1899, TUBGCP5
Sequence domains:
Gamma-tubulin complex component 4 Chain: I
Molecule details ›
Chain: I
Length: 667 amino acids
Theoretical weight: 76.18 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UGJ1 (Residues: 1-667; Coverage: 100%)
Gene names: 76P, GCP4, TUBGCP4
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.2Å
Relevant EMDB volumes: EMD-21060

Quick links

Citations

16 review citations

Mechanisms of microtubule organization in differentiated animal cells.
Akhmanova et al. (2022)
15 more

1 mention without citation

Asymmetric Molecular Architecture of the Human γ-Tubulin Ring Complex.
Wieczorek et al. (2020)