EC 1.13.11.52: Indoleamine 2,3-dioxygenase
Reaction catalysed:
D-tryptophan + O(2) = N-formyl-D-kynurenine
Systematic name:
D-tryptophan:oxygen 2,3-oxidoreductase (ring-opening)
Alternative Name(s):
- D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
- IDO
- Tryptophan pyrrolase
GO terms
Biochemical function:
- dioxygenase activity
- metal ion binding
- indoleamine 2,3-dioxygenase activity
- heme binding
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
- oxidoreductase activity
- electron transfer activity
- tryptophan 2,3-dioxygenase activity
Biological process:
- positive regulation of T cell apoptotic process
- negative regulation of T cell apoptotic process
- regulation of activated T cell proliferation
- positive regulation of apoptotic process
- negative regulation of T cell proliferation
- T cell proliferation
- swimming behavior
- 'de novo' NAD biosynthetic process from tryptophan
- kynurenic acid biosynthetic process
- multicellular organismal response to stress
- positive regulation of interleukin-12 production
- negative regulation of interleukin-10 production
- response to lipopolysaccharide
- tryptophan catabolic process to kynurenine
- female pregnancy
- inflammatory response
- tryptophan catabolic process
- positive regulation of type 2 immune response
- positive regulation of chronic inflammatory response
- positive regulation of T cell tolerance induction
- immune system process
Protein family (Pfam)
InterPro annotations