› 6v52

X-ray diffraction
1.78Å resolution

Function and Biology Details

Reaction catalysed: 
D-tryptophan + O(2) = N-formyl-D-kynurenine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Indoleamine 2,3-dioxygenase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 394 amino acids
Theoretical weight: 44.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14902 (Residues: 11-403; Coverage: 98%)
Gene names: IDO, IDO1, INDO
Sequence domains: Indoleamine 2,3-dioxygenase

Ligands and Environments

1 bound ligand:
Ligand QPV 2 x QPV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P212121
Unit cell:
a: 85.245Å b: 90.448Å c: 130.034Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.192 0.22
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors.
Hopkins et al. (2021)
2 more

4 mentions without citation

Put a ring on it: application of small aliphatic rings in medicinal chemistry.
Bauer et al. (2021)
3 more