› 6v38

Electron Microscopy
3.8Å resolution

Cryo-EM structure of Ca2+-bound hsSlo1 channel

Released:
DOI: 10.2210/pdb6v38/pdb
PDB entry 6v38 coloured by chain, front view.
PDB entry 6v38 coloured by chain, side view.
PDB entry 6v38 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular structures of the human Slo1 K+ channel in complex with β4.
Tao X, MacKinnon R
Elife 8 (2019)
PMID: 31815672
Related structures: EMD-21029

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171393 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-activated potassium channel subunit alpha-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1065 amino acids
Theoretical weight: 119.99 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q12791 (Residues: 66-1179; Coverage: 85%)
Gene names: KCNMA, KCNMA1, SLO
Sequence domains:

Ligands and Environments

4 bound ligands:
Ligand MG 4 x MG
Ligand CA 8 x CA
Ligand POV 32 x POV
Ligand CLR 12 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-21029
Expression system: Homo sapiens

Quick links

Citations

7 review citations

Ion channels and channelopathies in glomeruli.
Staruschenko et al. (2023)
6 more

17 mentions without citation

BK Channel Gating Mechanisms: Progresses Toward a Better Understanding of Variants Linked Neurological Diseases.
Cui J. (2021)
16 more