› 6v0s

X-ray diffraction
2.4Å resolution

Crystal structure of the bromodomain of human BRD9 bound to TG003

Released:
DOI: 10.2210/pdb6v0s/pdb
PDB 6v0s coloured by chain and viewed from the front.
PDB 6v0s coloured by chain and viewed from the side.
PDB 6v0s coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
Karim RM, Chan A, Zhu JY, Schönbrunn E
J Med Chem 63 3227-3237 (2020)
PMID: 32091206

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 14.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H8M2 (Residues: 134-243; Coverage: 18%)
  • Best match: Q9H8M2-1 (Residues: 14-134)
Gene names: BRD9, UNQ3040/PRO9856
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand EAE 2 x EAE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21212
Unit cell:
a: 74.634Å b: 123.013Å c: 31.693Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.192 0.23
Expression system: Escherichia coli BL21(DE3)

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Citations

3 review citations

Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy.
Wanior et al. (2021)
2 more