› 6v0q

X-ray diffraction
1.69Å resolution

Crystal structure of the bromodomain of human BRD7 bound to TG003

Released:
DOI: 10.2210/pdb6v0q/pdb
PDB entry 6v0q coloured by chain, front view.
PDB entry 6v0q coloured by chain, side view.
PDB entry 6v0q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
Karim RM, Chan A, Zhu JY, Schönbrunn E
J Med Chem 63 3227-3237 (2020)
PMID: 32091206

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-192484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 7 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 123 amino acids
Theoretical weight: 14.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NPI1 (Residues: 130-250; Coverage: 19%)
Gene names: BP75, BRD7, CELTIX1
Sequence domains: Bromodomain

Ligands and Environments

5 bound ligands:
Ligand EDO 4 x EDO
Ligand PO4 1 x PO4
Ligand CL 1 x CL
Ligand EAE 4 x EAE
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 59.97Å b: 36.78Å c: 118.96Å
α: 90° β: 101.768° γ: 90°
R-values:
R R work R free
0.182 0.181 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy.
Wanior et al. (2021)
4 more

1 mention without citation

Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains.
Karim et al. (2020)