6uzt

X-ray diffraction
1.8Å resolution

Crystal Structure of RPTP alpha

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 601 amino acids
Theoretical weight: 69.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P18433 (Residues: 211-802; Coverage: 76%)
Gene names: PTPA, PTPRA, PTPRL2
Sequence domains: Protein-tyrosine phosphatase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Unit cell:
a: 104.72Å b: 112.11Å c: 136.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.155 0.191
Expression system: Escherichia coli BL21