6uza

Electron Microscopy
3.08Å resolution

Cryo-EM structure of human TRPC6 in complex with antagonist AM-1473

Released:
Source organism: Homo sapiens
Related structures: EMD-20954

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
PDBe Complex ID:
PDB-CPX-195073 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Short transient receptor potential channel 6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 847 amino acids
Theoretical weight: 97.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y210 (Residues: 85-931; Coverage: 91%)
Gene names: TRP6, TRPC6
Sequence domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.08Å
Relevant EMDB volumes: EMD-20954
Expression system: Homo sapiens