› 6uz0

Electron Microscopy
3.24Å resolution

Cardiac sodium channel with flecainide

Released:
DOI: 10.2210/pdb6uz0/pdb
PDB entry 6uz0 coloured by chain, front view.
PDB entry 6uz0 coloured by chain, side view.
PDB entry 6uz0 coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the Cardiac Sodium Channel.
Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Cell 180 122-134.e10 (2020)
PMID: 31866066
Related structures: EMD-20949

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147338 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Green fluorescent protein; Sodium channel protein type 5 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 1838 amino acids
Theoretical weight: 209.04 KDa
Source organisms: Expression system: Mammalian 1 orthobornavirus
UniProt:
  • Canonical: P15389 (Residues: 1-1898; Coverage: 78%)
  • Canonical: P42212 (Residues: 2-238; Coverage: 100%)
Gene names: GFP, Scn5a
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
4 bound ligands:
Ligand NAG 2 x NAG
Ligand 9Z9 5 x 9Z9
Ligand 6OU 11 x 6OU
Ligand K4D 1 x K4D
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.24Å
Relevant EMDB volumes: EMD-20949
Expression system: Mammalian 1 orthobornavirus

Quick links

Citations

32 review citations

Epilepsy-Related Voltage-Gated Sodium Channelopathies: A Review.
Menezes et al. (2020)
31 more

20 mentions without citation

Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation.
Nathan et al. (2021)
19 more