› 6uy8

X-ray diffraction
1.65Å resolution

Crystal structure of the STAC3 tandem SH3 domains - P269R, K329N

Released:
DOI: 10.2210/pdb6uy8/pdb
PDB entry 6uy8 coloured by chain, front view.
PDB entry 6uy8 coloured by chain, side view.
PDB entry 6uy8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling.
Rufenach B, Christy D, Flucher BE, Bui JM, Gsponer J, Campiglio M, Van Petegem F
Structure 28 922-932.e5 (2020)
PMID: 32492370

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188627 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH3 and cysteine-rich domain-containing protein 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 14.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96MF2 (Residues: 245-364; Coverage: 33%)
Gene name: STAC3
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand EDO 5 x EDO
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P32
Unit cell:
a: 87.878Å b: 87.878Å c: 29.452Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.187 0.208
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Structure and function of STAC proteins: Calcium channel modulators and critical components of muscle excitation-contraction coupling.
Rufenach et al. (2021)
2 more