X-ray diffraction
1.6Å resolution

Crystal structure of the core domain of RNA helicase DDX17 with RNA pri-125a-oligo2

Source organism: Homo sapiens
Primary publication:
RNA Specificity and Autoregulation of DDX17, a Modulator of MicroRNA Biogenesis.
Cell Rep 29 4024-4035.e5 (2019)
PMID: 31851931

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Probable ATP-dependent RNA helicase DDX17 Chain: A
Molecule details ›
Chain: A
Length: 448 amino acids
Theoretical weight: 51.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q92841 (Residues: 111-556; Coverage: 61%)
Gene name: DDX17
Sequence domains:
125a-oligo2 Chain: B
Molecule details ›
Chain: B
Length: 10 nucleotides
Theoretical weight: 3.16 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3121
Unit cell:
a: 112.327Å b: 112.327Å c: 99.094Å
α: 90° β: 90° γ: 120°
R R work R free
0.175 0.175 0.197
Expression systems:
  • Escherichia coli
  • Not provided