X-ray diffraction
2Å resolution

Crystal structure of R173A variant of cytosolic fumarate hydratase from Leishmania major in a complex with S-malate


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Fumarate hydratase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 604 amino acids
Theoretical weight: 66.43 KDa
Source organism: Leishmania major strain Friedlin
Expression system: Escherichia coli
  • Canonical: E9AE57 (Residues: 1-568; Coverage: 100%)
Gene names: FH2, LMJF_29_1960
Sequence domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 65.624Å b: 85.072Å c: 240.423Å
α: 90° β: 90° γ: 90°
R R work R free
0.15 0.148 0.188
Expression system: Escherichia coli