6uo9

Electron Microscopy
4.8Å resolution

Human metabotropic GABA(B) receptor bound to agonist SKF97541 in its intermediate state 2

Released:
Source organism: Homo sapiens
Related structures: EMD-20823

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-131164 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Gamma-aminobutyric acid type B receptor subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 762 amino acids
Theoretical weight: 86.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UBS5 (Residues: 165-919; Coverage: 80%)
Gene names: GABBR1, GPRC3A
Sequence domains:
Gamma-aminobutyric acid type B receptor subunit 2 Chain: B
Molecule details ›
Chain: B
Length: 779 amino acids
Theoretical weight: 88.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75899 (Residues: 41-819; Coverage: 86%)
Gene names: GABBR2, GPR51, GPRC3B
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.8Å
Relevant EMDB volumes: EMD-20823
Expression system: Spodoptera frugiperda