X-ray diffraction
1.4Å resolution

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant complexed with AR-42


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
UBP-type domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 366 amino acids
Theoretical weight: 40.28 KDa
Source organism: Danio rerio
Expression system: Escherichia coli
  • Canonical: F8W4B7 (Residues: 60-419; Coverage: 33%)
Gene name: hdac6
Sequence domains: Histone deacetylase domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 55Å b: 60.67Å c: 121.83Å
α: 90° β: 90° γ: 90°
R R work R free
0.167 0.166 0.184
Expression system: Escherichia coli