› 6uko

X-ray diffraction
4.4Å resolution

Structure analysis of full-length mouse bcs1 complex

Released:
DOI: 10.2210/pdb6uko/pdb
PDB entry 6uko coloured by chain, front view.
PDB entry 6uko coloured by chain, side view.
PDB entry 6uko coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
Tang WK, Borgnia MJ, Hsu AL, Esser L, Fox T, de Val N, Xia D
Nat Struct Mol Biol 27 202-209 (2020)
PMID: 32042153

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190030 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial chaperone BCS1 Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 424 amino acids
Theoretical weight: 48.29 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9CZP5 (Residues: 1-418; Coverage: 100%)
Gene name: Bcs1l
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ADP 7 x ADP
Ligand MG 7 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 254.055Å b: 161.127Å c: 132.595Å
α: 90° β: 107.268° γ: 90°
R-values:
R R work R free
0.358 0.357 0.407
Expression system: Komagataella pastoris

Quick links

Citations

8 review citations

The assembly, regulation and function of the mitochondrial respiratory chain.
Vercellino et al. (2022)
7 more

5 mentions without citation

Bcs1, a novel target for fungicide.
Zhan et al. (2023)
4 more