Function and Biology Details
Reaction catalysed:
(1a) isocitrate + NADP(+) = 2-oxalosuccinate + NADPH
Biochemical function:
- not assigned
Biological process:
Cellular component:
Sequence domains:
- Immunoglobulin C1-set
- MHC class I alpha chain, alpha1 alpha2 domains
- Beta-2-Microglobulin
- Immunoglobulin/major histocompatibility complex, conserved site
- Immunoglobulin-like domain
- Immunoglobulin-like domain superfamily
- Immunoglobulin-like fold
- MHC class I-like antigen recognition-like superfamily
2 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135165 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, B alpha chain
Molecule details ›
Chains: A, D
Length: 298 amino acids
Theoretical weight: 34.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 298 amino acids
Theoretical weight: 34.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P01889 (Residues: 25-304; Coverage: 83%)
Sequence domains:
Beta-2-microglobulin
Molecule details ›
Chains: B, E
Length: 119 amino acids
Theoretical weight: 13.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Immunoglobulin C1-set domain
Length: 119 amino acids
Theoretical weight: 13.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P61769 (Residues: 1-119; Coverage: 100%)
Sequence domains: Immunoglobulin C1-set domain
Isocitrate dehydrogenase [NADP], mitochondrial
Molecule details ›
Chains: C, F
Length: 10 amino acids
Theoretical weight: 1.06 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 10 amino acids
Theoretical weight: 1.06 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P48735 (Residues: 134-143; Coverage: 2%)
