6uig

X-ray diffraction
3.2Å resolution

Crystal structure of human monoclonal antibody H7.200 in complex with H7N9 hemagglutinin HA1

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Hemagglutinin Chains: A, G
Molecule details ›
Chains: A, G
Length: 308 amino acids
Theoretical weight: 33.76 KDa
Source organism: Influenza A virus
Expression system: Homo sapiens
UniProt:
  • Canonical: R4NN21 (Residues: 19-320; Coverage: 54%)
Gene name: HA
H7.200 Fab heavy chain Chains: B, H
Molecule details ›
Chains: B, H
Length: 227 amino acids
Theoretical weight: 24.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
H7.200 Fab light chain Chains: C, L
Molecule details ›
Chains: C, L
Length: 214 amino acids
Theoretical weight: 23.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P4322
Unit cell:
a: 156.493Å b: 156.493Å c: 229.084Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.207 0.234
Expression system: Homo sapiens