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X-ray diffraction
2Å resolution

Crystal structure of the Fc fragment of PF06438179/GP1111 an infliximab biosimilar in a C-centered orthorhombic crystal form, Lot A

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin gamma-1 heavy chain Chain: A
Molecule details ›
Chain: A
Length: 255 amino acids
Theoretical weight: 28.36 KDa
Source organism: Homo sapiens
Expression system: Mus musculus
UniProt:
  • Canonical: P0DOX5 (Residues: 211-449; Coverage: 53%)
Sequence domains: Immunoglobulin C1-set domain

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: C2221
Unit cell:
a: 50.09Å b: 148.09Å c: 75.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.219
Expression system: Mus musculus