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Structure of Urocanate Hydratase from Trypanosoma cruzi in complex with NAD+

Source organism: Trypanosoma cruzi
Biochemical function: lyase activity
Biological process: histidine catabolic process to glutamate and formate
Cellular component: not assigned

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EC 4.2.1.49: Urocanate hydratase

Reaction catalysed:
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate = urocanate + H(2)O
Systematic name:
3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)
Alternative Name(s):
  • 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase
  • Imidazolonepropionate hydrolase
  • Urocanase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF17392
Domain description: Urocanase C-terminal domain
Occurring in:
  1. urocanate hydratase
The deposited structure of PDB entry 6uek contains 4 copies of Pfam domain PF17392 (Urocanase C-terminal domain) in urocanate hydratase. Showing 1 copy in chain A.

PF01175
Domain description: Urocanase Rossmann-like domain
Occurring in:
  1. urocanate hydratase
The deposited structure of PDB entry 6uek contains 4 copies of Pfam domain PF01175 (Urocanase Rossmann-like domain) in urocanate hydratase. Showing 1 copy in chain A.

PF17391
Domain description: Urocanase N-terminal domain
Occurring in:
  1. urocanate hydratase
The deposited structure of PDB entry 6uek contains 4 copies of Pfam domain PF17391 (Urocanase N-terminal domain) in urocanate hydratase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR023637
Domain description: Urocanase
Occurring in:
  1. urocanate hydratase
IPR023636
Domain description: Urocanase conserved site
Occurring in:
  1. urocanate hydratase
IPR035401
Domain description: Urocanase, C-terminal domain
Occurring in:
  1. urocanate hydratase
IPR038364
Domain description: Urocanase, central domain superfamily
Occurring in:
  1. urocanate hydratase
IPR035085
Domain description: Urocanase, Rossmann-like domain
Occurring in:
  1. urocanate hydratase
IPR036190
Domain description: Urocanase superfamily
Occurring in:
  1. urocanate hydratase
IPR035400
Domain description: Urocanase, N-terminal domain
Occurring in:
  1. urocanate hydratase

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