6ud4

Electron Microscopy
3.3Å resolution

GluA2 in complex with its auxiliary subunit CNIH3 in AS map II - (LBD-TMD-C3(AS) II)- with antagonist ZK200775, without NTD

Released:
Source organisms:
Primary publication:
Structures of the AMPA receptor in complex with its auxiliary subunit cornichon.
Science 366 1259-1263 (2019)
PMID: 31806817
Related structures: EMD-20733

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 889 amino acids
Theoretical weight: 99.53 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: P19491 (Residues: 1-868; Coverage: 98%)
Gene names: Glur2, Gria2
Sequence domains:
Protein cornichon homolog 3 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 174 amino acids
Theoretical weight: 20.26 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q6ZWS4 (Residues: 1-160; Coverage: 100%)
Gene name: Cnih3
Sequence domains: Cornichon protein

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-20733
Expression system: Homo sapiens