› 6ua3

X-ray diffraction
1.55Å resolution

Human Mcl-1 in complex with a modified Bim BH3 peptide

Released:
DOI: 10.2210/pdb6ua3/pdb
PDB entry 6ua3 coloured by chain, front view.
PDB entry 6ua3 coloured by chain, side view.
PDB entry 6ua3 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mandal T, Grant RA, Keating AE

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128964 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Induced myeloid leukemia cell differentiation protein Mcl-1 Chain: A
Molecule details ›
Chain: A
Length: 156 amino acids
Theoretical weight: 17.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07820 (Residues: 172-325; Coverage: 44%)
Gene names: BCL2L3, MCL1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Bcl-2-like protein 11 Chain: B
Molecule details ›
Chain: B
Length: 23 amino acids
Theoretical weight: 2.62 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O43521 (Residues: 146-166; Coverage: 11%)
Gene names: BCL2L11, BIM
Sequence domains: Bcl-x interacting, BH3 domain

Ligands and Environments

No bound ligands
3 modified residues:
Ligand NLE 1 x NLE
Ligand AIB 1 x AIB
Ligand ALC 1 x ALC

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 31.096Å b: 56.408Å c: 99.461Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.171 0.204
Expression systems:
  • Escherichia coli
  • Not provided

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