X-ray diffraction
1.26Å resolution

Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
WD repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 311 amino acids
Theoretical weight: 34.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
  • Canonical: P61964 (Residues: 24-334; Coverage: 93%)
Gene names: BIG3, WDR5

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P1
Unit cell:
a: 46.603Å b: 47.166Å c: 68.458Å
α: 88.2° β: 89.69° γ: 75.09°
R R work R free
0.133 0.132 0.159
Expression system: Escherichia coli K-12