6u6z

X-ray diffraction
2.1Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 535 amino acids
Theoretical weight: 61.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y3Z3 (Residues: 116-626; Coverage: 82%)
Gene names: MOP5, SAMHD1
Sequence domains: HD domain
DNA polymer TG(PST)TCA Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 6 nucleotides
Theoretical weight: 1.82 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P1
Unit cell:
a: 81.61Å b: 94.67Å c: 96.32Å
α: 72.9° β: 70.95° γ: 64.96°
R-values:
R R work R free
0.175 0.174 0.206
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided