6u6v

X-ray diffraction
1.9Å resolution

Crystal structure of human PD-1H / VISTA

Released:
Source organism: Homo sapiens
Primary publication:
Structural insight into T cell coinhibition by PD-1H (VISTA).
Proc. Natl. Acad. Sci. U.S.A. (2020)
PMID: 31919279

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
V-type immunoglobulin domain-containing suppressor of T-cell activation Chain: A
Molecule details ›
Chain: A
Length: 174 amino acids
Theoretical weight: 19.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H7M9 (Residues: 33-193; Coverage: 58%)
Gene names: C10orf54, PP2135, SISP1, UNQ730/PRO1412, VISTA, VSIR
Sequence domains: Immunoglobulin V-set domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 28.821Å b: 55.833Å c: 42.271Å
α: 90° β: 97.69° γ: 90°
R-values:
R R work R free
0.21 0.207 0.25
Expression system: Homo sapiens